翻訳と辞書 Words near each other ・ Apoplania chilensis ・ Apoplania penai ・ Apoplania valdiviana ・ Apoplast ・ Apoplexy ・ Apoplotrechus ・ APOPO ・ Apoprogoninae ・ Apoprotein ・ Apopse as vrethume ・ APOPT ・ Apopterygion ・ Apopterygion alta ・ Apoptosis ・ Apoptosis-antagonizing transcription factor ・ Apoptosis-inducing factor ・ Apoptosome ・ Apoptotic DNA fragmentation ・ Apoptygma Berzerk ・ Apoptygma Berzerk discography ・ Apopudobalia ・ Apopyllus ・ Apopyllus silvestrii ・ Apoquindo ・ Apoquindo Avenue ・ Apoquindo massacre ・ Apoquindo Waterfall ・ Apoquitaua River ・ Apor ・ Apor Péc Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Apoptosis-inducing factor ： ウィキペディア英語版 Apoptosis-inducing factor Apoptosis inducing factor is a flavoprotein. Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the mitochondrial membrane upon apoptosis. Normally it is found behind the outer membrane of the mitochondria and is therefore secluded from the nucleus. However, when the mitochondrion is damaged, it moves to the cytosol and to the nucleus. Inactivation of AIF leads to resistance of embryonic stem cells to death following the withdrawal of growth factors indicating that it is involved in apoptosis.〔 == Function == Apoptosis Inducing Factor (AIF) is a protein that triggers chromatin condensation and DNA fragmentation in a cell in order to induce programmed cell death. The mitochondrial AIF protein was found to be a caspase-independent death effector that can allow independent nuclei to undergo apoptotic changes. The process triggering apoptosis starts when the mitochondria releases AIF, which exits through the mitochondrial membrane, enters the cytosol, and finally ends up in the cell nucleus where it signals the cell to condense its chromosomes and fragment its DNA molecules in order to prepare for cell death. Recently, researchers have discovered that AIF's activity is dependent upon the type of cell, the apoptotic insult, and its DNA-binding ability. AIF also plays a significant role in the mitochondrial respiratory chain and metabolic redox reactions. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Apoptosis-inducing factor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.